The present investigation was designed with the objective of role of electrolyte on the drug release from aceclofenac floating minimatrices. The formulations were fabricated by a simple extrusion technique. Minimatrices of size 1.14-1.5 mm were prepared by different drug: polymer ratio of 1:1, 1:2, 1:3 ratios. Calcium carbonate and calcium chloride were incorporated to produce effervescence and as an electrolyte respectively. Pale ash to white coloured minimatrics showed no interactions in DSC Thermograms. Although Aceclofenac because of its weakly acidic nature was poorly soluble in gastric pH, calcium chloride as an electrolyte does enhanced the solubility and henceforth the drug release as well as buoyancy, but seldom influenced other parameters.
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